Proline–Proline Dyad in the Fusion Peptide of the Murine β–Coronavirus Spike Protein’s S2 Domain Modulates Its Neuroglial Tropism

The β-Coronavirus mouse hepatitis virus (MHV-A59)-RSA59 has a patent stretch of fusion peptide (FP) containing two consecutive central prolines (PP) in the S2 domain of the Spike protein. Our previous studies compared the PP-containing fusogenic-demyelinating strain RSA59(PP) to its one proline-dele...

Descripción completa

Detalles Bibliográficos
Autores principales: Safiriyu, Abass Alao, Mulchandani, Vaishali, Anakkacheri, Mohammed Nahaf, Pal, Debnath, Das Sarma, Jayasri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865228/
https://www.ncbi.nlm.nih.gov/pubmed/36680255
http://dx.doi.org/10.3390/v15010215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865228/
https://www.ncbi.nlm.nih.gov/pubmed/36680255
http://dx.doi.org/10.3390/v15010215

Ejemplares similares