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Proline–Proline Dyad in the Fusion Peptide of the Murine β–Coronavirus Spike Protein’s S2 Domain Modulates Its Neuroglial Tropism
The β-Coronavirus mouse hepatitis virus (MHV-A59)-RSA59 has a patent stretch of fusion peptide (FP) containing two consecutive central prolines (PP) in the S2 domain of the Spike protein. Our previous studies compared the PP-containing fusogenic-demyelinating strain RSA59(PP) to its one proline-dele...
Autores principales: | Safiriyu, Abass Alao, Mulchandani, Vaishali, Anakkacheri, Mohammed Nahaf, Pal, Debnath, Das Sarma, Jayasri |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865228/ https://www.ncbi.nlm.nih.gov/pubmed/36680255 http://dx.doi.org/10.3390/v15010215 |
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