Endoplasmic Reticulum Stress and Cancer: Could Unfolded Protein Response Be a Druggable Target for Cancer Therapy?

Unfolded protein response (UPR) is an adaptive response which is used for re-establishing protein homeostasis, and it is triggered by endoplasmic reticulum (ER) stress. Specific ER proteins mediate UPR activation, after dissociation from chaperone Glucose-Regulated Protein 78 (GRP78). UPR can decrea...

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Detalles Bibliográficos
Autores principales: Bonsignore, Gregorio, Martinotti, Simona, Ranzato, Elia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865308/
https://www.ncbi.nlm.nih.gov/pubmed/36675080
http://dx.doi.org/10.3390/ijms24021566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865308/
https://www.ncbi.nlm.nih.gov/pubmed/36675080
http://dx.doi.org/10.3390/ijms24021566

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