3D-QSAR Studies, Molecular Docking, Molecular Dynamic Simulation, and ADMET Proprieties of Novel Pteridinone Derivatives as PLK1 Inhibitors for the Treatment of Prostate Cancer

Overexpression of polo-like kinase 1 (PLK1) has been found in many different types of cancers. With its essential role in cell proliferation, PLK1 has been determined to be a broad-spectrum anti-cancer target. In this study, 3D-QSAR, molecular docking, and molecular dynamics (MD) simulations were ap...

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Detalles Bibliográficos
Autores principales: Er-rajy, Mohammed, El fadili, Mohamed, Imtara, Hamada, Saeed, Aamir, Ur Rehman, Abid, Zarougui, Sara, Abdullah, Shaef A., Alahdab, Ahmad, Parvez, Mohammad Khalid, Elhallaoui, Menana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865323/
https://www.ncbi.nlm.nih.gov/pubmed/36676076
http://dx.doi.org/10.3390/life13010127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865323/
https://www.ncbi.nlm.nih.gov/pubmed/36676076
http://dx.doi.org/10.3390/life13010127

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