Lactone Stabilized by Crosslinked Cyclodextrin Metal-Organic Frameworks to Improve Local Bioavailability of Topotecan in Lung Cancer

The protection of unstable anticancer molecules and their delivery to lesions are challenging issues in cancer treatment. Topotecan (TPT), a classic cytotoxic drug, is widely used for treating refractory lung cancer. However, the therapeutic effects of TPT are jeopardized by its active lactone form...

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Detalles Bibliográficos
Autores principales: Xiong, Ting, Guo, Tao, He, Yaping, Cao, Zeying, Xu, Huipeng, Wu, Wenting, Wu, Li, Zhu, Weifeng, Zhang, Jiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865350/
https://www.ncbi.nlm.nih.gov/pubmed/36678769
http://dx.doi.org/10.3390/pharmaceutics15010142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865350/
https://www.ncbi.nlm.nih.gov/pubmed/36678769
http://dx.doi.org/10.3390/pharmaceutics15010142

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