Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A

We designed colon-targeted trans-cinnamic acid (tCA) and synthesized its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA). We evaluated the anti-colitic activity of colon-targeted tCA using a dinitrobenzenesulfonic acid-induced rat colitis model. The conjugates lowered the distribut...

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Detalles Bibliográficos
Autores principales: Kang, Changyu, Kim, Jaejeong, Ju, Sanghyun, Cho, Heeyeong, Kim, Hyun Young, Yoon, In-Soo, Yoo, Jin-Wook, Jung, Yunjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865397/
https://www.ncbi.nlm.nih.gov/pubmed/36678670
http://dx.doi.org/10.3390/pharmaceutics15010041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865397/
https://www.ncbi.nlm.nih.gov/pubmed/36678670
http://dx.doi.org/10.3390/pharmaceutics15010041

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