Cargando…

Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A

We designed colon-targeted trans-cinnamic acid (tCA) and synthesized its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA). We evaluated the anti-colitic activity of colon-targeted tCA using a dinitrobenzenesulfonic acid-induced rat colitis model. The conjugates lowered the distribut...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, Changyu, Kim, Jaejeong, Ju, Sanghyun, Cho, Heeyeong, Kim, Hyun Young, Yoon, In-Soo, Yoo, Jin-Wook, Jung, Yunjin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865397/ https://www.ncbi.nlm.nih.gov/pubmed/36678670 http://dx.doi.org/10.3390/pharmaceutics15010041

Ejemplares similares

N-Succinylaspartic-Acid-Conjugated Riluzole Is a Safe and Potent Colon-Targeted Prodrug of Riluzole against DNBS-Induced Rat Colitis
por: Kim, Jaejeong, et al.
Publicado: (2023)

Dapsone Azo-Linked with Two Mesalazine Moieties Is a “Me-Better” Alternative to Sulfasalazine
por: Kang, Changyu, et al.
Publicado: (2022)

A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats
por: Kim, Soojin, et al.
Publicado: (2020)

A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
por: Yang, Yejin, et al.
Publicado: (2018)

Niacin Ameliorates Neuro-Inflammation in Parkinson’s Disease via GPR109A
por: Giri, Banabihari, et al.
Publicado: (2019)

GPR109A and Vascular Inflammation
por: Chai, Joshua T., et al.
Publicado: (2013)

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a
por: Sun, Yonggan, et al.
Publicado: (2023)

Conjugation of Amisulpride, an Anti-Psychotic Agent, with 5-Aminosalicylic Acid via an Azo Bond Yields an Orally Active Mutual Prodrug against Rat Colitis
por: Kim, Wooseong, et al.
Publicado: (2019)

Upregulation of GPR109A in Parkinson’s Disease
por: Wakade, Chandramohan, et al.
Publicado: (2014)

GPR109A activation and aging liver
por: Jadeja, Ravirajsinh N., et al.
Publicado: (2019)

Eletrophilic Chemistry of Tranilast Is Involved in Its Anti-Colitic Activity via Nrf2-HO-1 Pathway Activation
por: Jeong, Seongkeun, et al.
Publicado: (2021)

Colon-targeted delivery of cyclosporine A using dual-functional Eudragit(®) FS30D/PLGA nanoparticles ameliorates murine experimental colitis
por: Naeem, Muhammad, et al.
Publicado: (2018)

Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx
por: Zhang, Shu‐jie, et al.
Publicado: (2021)

Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
por: Adepu, Kiran Kumar, et al.
Publicado: (2021)

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy
por: Naeem, Muhammad, et al.
Publicado: (2015)

Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice
por: ZHU, BINGYAN, et al.
Publicado: (2016)

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
por: Taing, Kyle, et al.
Publicado: (2022)

N-benzyl-N-methyldecan-1-amine and its derivative mitigate 2,4- dinitrobenzenesulfonic acid-induced colitis and collagen-induced rheumatoid arthritis
por: Kim, Ji Eun, et al.
Publicado: (2023)

Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson’s disease symptoms without side effects
por: Wakade, Chandramohan, et al.
Publicado: (2015)

Methyl cinnamate protects against dextran sulfate sodium-induced colitis in mice by inhibiting the MAPK signaling pathway: Methyl cinnamate in dextran sulfate sodium-induced colitis
por: E, Lilin, et al.
Publicado: (2023)

β-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling
por: Lee, A Kyoung, et al.
Publicado: (2020)

2,3,4,5,6-Pentafluoro-trans-cinnamic acid
por: Navarrete, Angélica, et al.
Publicado: (2013)

Trans-Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes
por: Kang, Nam Hyeon, et al.
Publicado: (2019)

trans-Cinnamic acid-induced leaf expansion involves an auxin-independent component
por: Kurepa, Jasmina, et al.
Publicado: (2019)

Opposing effects of trans‐ and cis‐cinnamic acid during rice coleoptile elongation
por: Vlaminck, Lena, et al.
Publicado: (2022)

pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis
por: Oshi, Murtada A., et al.
Publicado: (2021)

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis
por: Jadeja, Ravirajsinh N., et al.
Publicado: (2019)

Short-Term Effects of Trans-Cinnamic Acid on the Metabolism of Zea mays L. Roots
por: López-González, David, et al.
Publicado: (2023)

Creatininium cinnamate
por: Ali, A. Jahubar, et al.
Publicado: (2011)

Role and species–specific expression of colon T cell homing receptor GPR15 in colitis
por: Nguyen, Linh P., et al.
Publicado: (2014)

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
por: Chen, Jin-Ran, et al.
Publicado: (2021)

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism
por: Geisler, Caroline E., et al.
Publicado: (2021)

Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes
por: Kim, Wooseong, et al.
Publicado: (2017)

Rational Engineering of Phenylalanine Accumulation in Pseudomonas taiwanensis to Enable High-Yield Production of Trans-Cinnamate
por: Otto, Maike, et al.
Publicado: (2019)

Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells
por: Chai, Joshua T., et al.
Publicado: (2013)

Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A
por: Liu, Shilong, et al.
Publicado: (2022)

Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy
por: Bhandari, Dipendra, et al.
Publicado: (2022)

Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15
por: Van, Nguyen T., et al.
Publicado: (2023)

CD4(+)-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
por: Dicker, Martina, et al.
Publicado: (2022)

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD(+)/nicotinamide
por: Horimatsu, Tetsuo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_7j34mvanum0od8nv24ojhcad9h