Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca(2+) Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins

The trafficking of transient receptor potential (TRP) channels to the plasma membrane and the release of calcitonin gene-related peptide (CGRP) from trigeminal ganglion neurons (TGNs) are implicated in some aspects of chronic migraines. These exocytotic processes are inhibited by cleavage of SNAREs...

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Detalles Bibliográficos
Autores principales: Belinskaia, Mariia, Wang, Jiafu, Kaza, Seshu Kumar, Antoniazzi, Caren, Zurawski, Tomas, Dolly, J. Oliver, Lawrence, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865456/
https://www.ncbi.nlm.nih.gov/pubmed/36674850
http://dx.doi.org/10.3390/ijms24021338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865456/
https://www.ncbi.nlm.nih.gov/pubmed/36674850
http://dx.doi.org/10.3390/ijms24021338

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