New Methylcitrate Synthase Inhibitor Induces Proteolysis, Lipid Degradation and Pyruvate Excretion in Paracoccidioides brasiliensis

Background: Paracoccidioidomycosis is a systemic mycosis caused by the inhalation of conidia of the genus Paracoccidioides. During the infectious process, fungal cells use several carbon sources, leading to the production of propionyl-CoA. The latter is metabolized by the methylcitrate synthase, a k...

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Detalles Bibliográficos
Autores principales: Rocha, Olivia Basso, Freitas e Silva, Kleber Santiago, Santos, Thaynara Gonzaga, Moraes, Dayane, Assunção, Leandro do Prado, Bailão, Alexandre Melo, Soares, Célia Maria de Almeida, Pereira, Maristela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865517/
https://www.ncbi.nlm.nih.gov/pubmed/36675929
http://dx.doi.org/10.3390/jof9010108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865517/
https://www.ncbi.nlm.nih.gov/pubmed/36675929
http://dx.doi.org/10.3390/jof9010108

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