Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors

The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compoun...

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Detalles Bibliográficos
Autores principales: Haque, M. Akiful, Marathakam, Akash, Rana, Ritesh, Almehmadi, Samar J, Tambe, Vishal B., Charde, Manoj S., Islam, Fahadul, Siddiqui, Falak A., Culletta, Giulia, Almerico, Anna Maria, Tutone, Marco, Khan, Sharuk L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865878/
https://www.ncbi.nlm.nih.gov/pubmed/36677558
http://dx.doi.org/10.3390/molecules28020501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865878/
https://www.ncbi.nlm.nih.gov/pubmed/36677558
http://dx.doi.org/10.3390/molecules28020501

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