Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study

This study presents proof of concept for designing a novel HIV-1 covalent inhibitor targeting the highly conserved Tyr318 in the HIV-1 non-nucleoside reverse transcriptase inhibitors binding pocket to improve the drug resistance profiles. The target inhibitor ZA-2 with a fluorosulfate warhead in the...

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Detalles Bibliográficos
Autores principales: Zhou, Zhenzhen, Meng, Bairu, An, Jiaqi, Zhao, Fabao, Sun, Yanying, Zeng, Dan, Wang, Wenna, Gao, Shenghua, Xia, Yu, Dun, Caiyun, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Kang, Dongwei, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865928/
https://www.ncbi.nlm.nih.gov/pubmed/36674730
http://dx.doi.org/10.3390/ijms24021215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865928/
https://www.ncbi.nlm.nih.gov/pubmed/36674730
http://dx.doi.org/10.3390/ijms24021215

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