Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer

It has been shown that phosphodiesterase 5 (PDE5) inhibitors have anticancer effects in a variety of malignancies in both in vivo and in vitro experiments. The role of cGMP elevation in colorectal carcinoma (CRC) has been extensively studied. Additionally, DNA topoisomerase II (Topo II) inhibition i...

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Detalles Bibliográficos
Autores principales: Ammar, Lina, Lin, Hung-Yu, Shih, Shou-Ping, Tsai, Tsen-Ni, Syu, Yu-Ting, Abdel-Halim, Mohammad, Hwang, Tsong-Long, Abadi, Ashraf H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866191/
https://www.ncbi.nlm.nih.gov/pubmed/36677898
http://dx.doi.org/10.3390/molecules28020840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866191/
https://www.ncbi.nlm.nih.gov/pubmed/36677898
http://dx.doi.org/10.3390/molecules28020840

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