Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model

Novel furoxan/coumarin hybrids were synthesized, and pharmacologic studies showed that the compounds displayed potent antiproliferation activities via downregulating both the phosphatidylinositide 3-kinase (PI3K) pathway and the mitogen-activated protein kinase (MAPK) pathway. To investigate the pre...

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Detalles Bibliográficos
Autores principales: Yuan, Yawen, Li, Zhihong, Wang, Ke, Zhang, Shunguo, He, Qingfeng, Liu, Lucy, Tang, Zhijia, Zhu, Xiao, Chen, Ying, Cai, Weimin, Peng, Chao, Xiang, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866629/
https://www.ncbi.nlm.nih.gov/pubmed/36677893
http://dx.doi.org/10.3390/molecules28020837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866629/
https://www.ncbi.nlm.nih.gov/pubmed/36677893
http://dx.doi.org/10.3390/molecules28020837

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