Cargando…

Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model

Novel furoxan/coumarin hybrids were synthesized, and pharmacologic studies showed that the compounds displayed potent antiproliferation activities via downregulating both the phosphatidylinositide 3-kinase (PI3K) pathway and the mitogen-activated protein kinase (MAPK) pathway. To investigate the pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Yawen, Li, Zhihong, Wang, Ke, Zhang, Shunguo, He, Qingfeng, Liu, Lucy, Tang, Zhijia, Zhu, Xiao, Chen, Ying, Cai, Weimin, Peng, Chao, Xiang, Xiaoqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866629/ https://www.ncbi.nlm.nih.gov/pubmed/36677893 http://dx.doi.org/10.3390/molecules28020837

Ejemplares similares

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs
por: Yuan, Yawen, et al.
Publicado: (2022)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS
por: Zhang, Chengyin, et al.
Publicado: (2018)

Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS
por: Zhang, Jili, et al.
Publicado: (2019)

Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
por: Jia, Qiuyu, et al.
Publicado: (2022)

Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS
por: Xu, Dan, et al.
Publicado: (2020)

Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS
por: Zeng, Qingyuan, et al.
Publicado: (2022)

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS
por: Fan, Hong-wei, et al.
Publicado: (2015)

Development and validation of a LC–MS/MS method for quantification of hetrombopag for pharmacokinetics study
por: Chen, Tao, et al.
Publicado: (2015)

Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study()
por: Moola, Kumar S., et al.
Publicado: (2015)

The LC-MS/MS-Based Measurement of Isopimaric Acid in Rat Plasma and Application of Pharmacokinetics
por: Huang, Doudou, et al.
Publicado: (2021)

LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study
por: Cui, Lili, et al.
Publicado: (2022)

Rapid and Sensitive Determination of Timosaponin AIII in Rat Plasma by LC-MS/MS and Its Pharmacokinetic Application
por: Liu, Yanping, et al.
Publicado: (2013)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
por: Yao, Yu-Feng, et al.
Publicado: (2018)

Simultaneous Determination of Atorvastatin and Aspirin in Human Plasma by LC–MS/MS: Its Pharmacokinetic Application
por: Gajula, Ramakrishna, et al.
Publicado: (2012)

Bioanalytical Method for Carbocisteine in Human Plasma by Using LC-MS/MS: A Pharmacokinetic Application
por: Dhanure, Shivanand, et al.
Publicado: (2014)

Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study
por: Ponnuru, Venkata Suresh, et al.
Publicado: (2012)

Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
por: Liu, Lu, et al.
Publicado: (2016)

Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study
por: Deng, Yingbin, et al.
Publicado: (2017)

LC-MS/MS Validation Analysis of Trastuzumab Using dSIL Approach for Evaluating Pharmacokinetics
por: Budhraja, Rohit H., et al.
Publicado: (2016)

The Pharmacokinetics in Mice and Cell Uptake of Thymus Immunosuppressive Pentapeptide Using LC-MS/MS Analysis
por: Chen, Shang, et al.
Publicado: (2022)

Effect of Dexamethasone on Abiraterone Pharmacokinetics in Mice: Determined by LC/MS Analysis
por: Deb, Subrata, et al.
Publicado: (2023)

Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS
por: Zagol-Ikapitte, Irene, et al.
Publicado: (2010)

Simultaneous Quantification of Baricitinib and Methotrexate in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study
por: Veeraraghavan, Sridhar, et al.
Publicado: (2016)

Pharmacokinetic analysis and tissue distribution of Vam3 in the rat by a validated LC-MS/MS method
por: Zhang, Ruixia, et al.
Publicado: (2015)

Precolumn derivatization LC–MS/MS method for the determination and pharmacokinetic study of glucosamine in human plasma and urine
por: Song, Min, et al.
Publicado: (2012)

Simultaneous determination of amlodipine, valsartan and hydrochlorothiazide by LC–ESI-MS/MS and its application to pharmacokinetics in rats
por: Gadepalli, Shankar Ganesh, et al.
Publicado: (2014)

Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method
por: Li, Chi-Lin, et al.
Publicado: (2018)

Development of an LC–MS/MS method for the quantitation of deoxyglycychloxazol in rat plasma and its application in pharmacokinetic study()
por: Li, Rongshan, et al.
Publicado: (2016)

Validated LC-MS/MS Method for the Determination of Scopoletin in Rat Plasma and Its Application to Pharmacokinetic Studies
por: Zeng, Yingchun, et al.
Publicado: (2015)

Development of an LC-MS/MS Method for ARV-110, a PROTAC Molecule, and Applications to Pharmacokinetic Studies
por: Nguyen, Thi-Thao-Linh, et al.
Publicado: (2022)

Pharmacokinetics of Nafamostat, a Potent Serine Protease Inhibitor, by a Novel LC-MS/MS Analysis
por: Oh, Hyeon Seok, et al.
Publicado: (2022)

A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS
por: Chai, Xiao-Ning, et al.
Publicado: (2022)

Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia
por: Shen, Xin, et al.
Publicado: (2022)

Establishment of LC-MS/MS Method for Determination of GMDTC in Rat Plasma and Its Application in Preclinical Pharmacokinetics
por: Hu, Wei, et al.
Publicado: (2023)

A Novel Method for Predicting the Human Inherent Clearance and Its Application in the Study of the Pharmacokinetics and Drug–Drug Interaction between Azidothymidine and Fluconazole Mediated by UGT Enzyme
por: Yuan, Yawen, et al.
Publicado: (2021)

LC–MS/MS determination and pharmacokinetic study of bergenin, the main bioactive component of Bergenia purpurascens after oral administration in rats
por: Li, Bao-Hong, et al.
Publicado: (2013)

Bioequivalance and pharmacokinetic study of febuxostat in human plasma by using LC-MS/MS with liquid liquid extraction method
por: Chandu, Babu Rao, et al.
Publicado: (2013)

LC–MS/MS determination and pharmacokinetic study of columbianadin in rat plasma after intravenous administration of pure columbianadin
por: Chang, Yan-xu, et al.
Publicado: (2014)

Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study
por: Lu, Wei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ehnm4unc4qdvm75u2ukttm4v7t