Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)—In Vitro Testing

Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with can...

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Detalles Bibliográficos
Autores principales: Tátrai, Péter, Erdő, Franciska, Krajcsi, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866820/
https://www.ncbi.nlm.nih.gov/pubmed/36678658
http://dx.doi.org/10.3390/pharmaceutics15010029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866820/
https://www.ncbi.nlm.nih.gov/pubmed/36678658
http://dx.doi.org/10.3390/pharmaceutics15010029

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