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Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)—In Vitro Testing
Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with can...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866820/ https://www.ncbi.nlm.nih.gov/pubmed/36678658 http://dx.doi.org/10.3390/pharmaceutics15010029 |