Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop

In aqueous solutions, cobra cytotoxins (CTX), three-finger folded proteins, exhibit conformational equilibrium between conformers with either cis or trans peptide bonds in the N-terminal loop (loop-I). The equilibrium is shifted to the cis form in toxins with a pair of adjacent Pro residues in this...

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Detalles Bibliográficos
Autores principales: Dubovskii, Peter V., Ignatova, Anastasia A., Alekseeva, Anna S., Starkov, Vladislav G., Boldyrev, Ivan A., Feofanov, Alexey V., Utkin, Yuri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866941/
https://www.ncbi.nlm.nih.gov/pubmed/36668826
http://dx.doi.org/10.3390/toxins15010006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866941/
https://www.ncbi.nlm.nih.gov/pubmed/36668826
http://dx.doi.org/10.3390/toxins15010006

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