Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity

Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of an Apx-loaded nanostructured lipid carrier (NLC) to...

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Detalles Bibliográficos
Autores principales: Zaky, Mohamed F., Megahed, Mohamed A., Hammady, Taha M., Gad, Shadeed, Ghorab, Mamdouh Mostafa, El-Say, Khalid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867073/
https://www.ncbi.nlm.nih.gov/pubmed/36678709
http://dx.doi.org/10.3390/pharmaceutics15010080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867073/
https://www.ncbi.nlm.nih.gov/pubmed/36678709
http://dx.doi.org/10.3390/pharmaceutics15010080

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