Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection

For the selective elimination of deleterious cells (e.g., cancer cells and virus-infected cells), the use of a cytotoxic gene is a promising approach. DNA-based systems have achieved selective cell elimination but risk insertional mutagenesis. Here, we developed a synthetic mRNA-based system to sele...

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Detalles Bibliográficos
Autores principales: Free, Kendall, Nakanishi, Hideyuki, Itaka, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867180/
https://www.ncbi.nlm.nih.gov/pubmed/36678842
http://dx.doi.org/10.3390/pharmaceutics15010213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867180/
https://www.ncbi.nlm.nih.gov/pubmed/36678842
http://dx.doi.org/10.3390/pharmaceutics15010213

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