Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease

COVID-19 and especially Long COVID are associated with severe CNS symptoms and may place persons at risk to develop long-term cognitive impairments. Here, we show that two non-infective models of SARS-CoV-2 can cross the blood–brain barrier (BBB) and induce neuroinflammation, a major mechanism under...

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Detalles Bibliográficos
Autores principales: Erickson, Michelle A., Logsdon, Aric F., Rhea, Elizabeth M., Hansen, Kim M., Holden, Sarah J, Banks, William A, Smith, Jessica L., German, Cody, Farr, Susan A., Morley, John E., Weaver, Riley R, Hirsch, Alec J., Kovac, Andrej, Kontsekova, Eva, Baumann, Kristen K., Omer, Mohamed A., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2023
Materias:
Full-length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867649/
https://www.ncbi.nlm.nih.gov/pubmed/36682515
http://dx.doi.org/10.1016/j.bbi.2023.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867649/
https://www.ncbi.nlm.nih.gov/pubmed/36682515
http://dx.doi.org/10.1016/j.bbi.2023.01.010

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