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Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

We previously reported that IGFBP7 plays a role in maintaining mRNA stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction in gastric cancer (GC). Clinical cohort studies had implied an oncogenic role of IGFBP7 in GC. However, the molecular mechanism of IGFBP7 in GC progression remains unknown...

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Detalles Bibliográficos
Autores principales: Li, Dandan, Xia, Lingyun, Huang, Pan, Wang, Zidi, Guo, Qiwei, Huang, Congcong, Leng, Weidong, Qin, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867714/
https://www.ncbi.nlm.nih.gov/pubmed/36681667
http://dx.doi.org/10.1038/s41420-023-01336-x