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Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data

Effective dimension reduction is essential for single cell RNA-seq (scRNAseq) analysis. Principal component analysis (PCA) is widely used, but requires continuous, normally-distributed data; therefore, it is often coupled with log-transformation in scRNAseq applications, which can distort the data a...

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Detalles Bibliográficos
Autores principales: Hsu, Lauren L., Culhane, Aedín C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867729/
https://www.ncbi.nlm.nih.gov/pubmed/36681709
http://dx.doi.org/10.1038/s41598-022-26434-1