SPRTN patient variants cause global-genome DNA-protein crosslink repair defects

DNA-protein crosslinks (DPCs) are pervasive DNA lesions that are induced by reactive metabolites and various chemotherapeutic agents. Here, we develop a technique for the Purification of x-linked Proteins (PxP), which allows identification and tracking of diverse DPCs in mammalian cells. Using PxP,...

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Detalles Bibliográficos
Autores principales: Weickert, Pedro, Li, Hao-Yi, Götz, Maximilian J., Dürauer, Sophie, Yaneva, Denitsa, Zhao, Shubo, Cordes, Jacqueline, Acampora, Aleida C., Forne, Ignasi, Imhof, Axel, Stingele, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867749/
https://www.ncbi.nlm.nih.gov/pubmed/36681662
http://dx.doi.org/10.1038/s41467-023-35988-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867749/
https://www.ncbi.nlm.nih.gov/pubmed/36681662
http://dx.doi.org/10.1038/s41467-023-35988-1

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