Cargando…

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the mammary gland. The mechanisms leading to SQM in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juan, Lucía San, Freije, Ana, Sanz-Gómez, Natalia, Jiménez-Matías, Beatriz, Pleguezuelos-Manzano, Cayetano, Sanz, J. Ramón, de Diego, Ernesto, Naranjo, Sara, Clevers, Hans, Gandarillas, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867756/ https://www.ncbi.nlm.nih.gov/pubmed/36681661 http://dx.doi.org/10.1038/s41420-023-01330-3

Ejemplares similares

Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint
por: de Pedro, Isabel, et al.
Publicado: (2018)

The DNA damage response links human squamous proliferation with differentiation
por: Molinuevo, Rut, et al.
Publicado: (2020)

The mitosis-differentiation checkpoint, another guardian of the epidermal genome
por: Gandarillas, Alberto, et al.
Publicado: (2015)

Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia
por: Williams, Rebecca, et al.
Publicado: (2021)

Author Correction: Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs
por: Pou Casellas, Carla, et al.
Publicado: (2023)

Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs
por: Pou Casellas, Carla, et al.
Publicado: (2023)

Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells
por: Pleguezuelos‐Manzano, Cayetano, et al.
Publicado: (2020)

A Mitosis Block Links Active Cell Cycle with Human Epidermal Differentiation and Results in Endoreplication
por: Zanet, Jennifer, et al.
Publicado: (2010)

USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy
por: Campos-Iglesias, Diana, et al.
Publicado: (2023)

Evaluation of myeloid metaplasia in canine mixed mammary tumors
por: Campos, Cecilia B, et al.
Publicado: (2013)

FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53
por: Molinuevo, R, et al.
Publicado: (2017)

UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer
por: Krupina, Ksenia, et al.
Publicado: (2017)

A Case of Squamous Metaplasia of the Stomach
por: Jeon, Moo Song, et al.
Publicado: (2013)

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis
por: Sanz-Gómez, Natalia, et al.
Publicado: (2020)

Experimental Squamous Metaplasia and Squamous Epithelioma Formation in the Pituitary of the Rat
por: Cheetham, H. D.
Publicado: (1963)

Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells
por: Alonso-Lecue, Pilar, et al.
Publicado: (2017)

Alveolar Squamous Cell Metaplasia: Preneoplastic Lesion?
por: Handra-Luca, Adriana
Publicado: (2018)

Squamous Metaplasia of the Stomach Associated with Lymphoma Infiltration
por: Iwamuro, Masaya, et al.
Publicado: (2021)

Mitotic checkpoints, MUGs and kinetochores
por: Brinkley, Bill R.
Publicado: (2013)

Conservative Management of Unusual Keratinising Squamous Metaplasia of the Bladder in a 28-Year-Old Female and Overview of the Literature
por: Vázquez Alonso, Fernando, et al.
Publicado: (2012)

Chronic Cystitis Associated With Keratinizing Squamous Metaplasia Progressing to Squamous Papilloma()
por: Puzio, Corinne, et al.
Publicado: (2014)

Squamous metaplasia of the rete ovarii in a Zebu cow
por: Santos, Renato Lima, et al.
Publicado: (2012)

Squamous Metaplasia and Keratinization in Cystic Hyperplasia of the Human Breast
por: Rangam, C. Mohan
Publicado: (1950)

Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection
por: Mori, Eri, et al.
Publicado: (2021)

Squamous Metaplasia of the Colon Following Severe COVID-19
por: Masuda, Satoshi, et al.
Publicado: (2022)

Gastric squamous metaplasia observed by image‐enhanced endoscopy
por: Iwata, Eri, et al.
Publicado: (2023)

Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells
por: Lee, Kyunghee, et al.
Publicado: (2011)

OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases
por: Ji, Wenbin, et al.
Publicado: (2016)

Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells.
por: Cameron, G, et al.
Publicado: (1989)

Renal Pelviceal Keratinizing Squamous Metaplasia with Sparing of Pyramidal Zones
por: Siderits, Richard H., et al.
Publicado: (2012)

Squamous Metaplasia in Pleomorphic Adenoma: A Diagnostic and Prognostic Enigma
por: Sharma, Swati, et al.
Publicado: (2018)

The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint
por: Gandarillas, Alberto
Publicado: (2012)

In-Silico Modeling of the Mitotic Spindle Assembly Checkpoint
por: Ibrahim, Bashar, et al.
Publicado: (2008)

Targeting the Mitotic Checkpoint to Kill Tumor Cells
por: Janssen, Aniek, et al.
Publicado: (2010)

Some assembly required: Redefining the mitotic checkpoint
por: Meadows, John C., et al.
Publicado: (2017)

Analysis of the role of GSK3 in the mitotic checkpoint
por: Rashid, M. S., et al.
Publicado: (2018)

Regulation of mitotic progression by the spindle assembly checkpoint
por: Lischetti, Tiziana, et al.
Publicado: (2015)

Basis of catalytic assembly of the mitotic checkpoint complex
por: Faesen, Alex C., et al.
Publicado: (2017)

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
por: Geurts, Maarten H, et al.
Publicado: (2021)

Pleomorphic adenoma with squamous and appendageal metaplasia mimicking mucoepidermoid carcinoma on cytology
por: Batrani, Meenakshi, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_1pdknqa92ffdm1fogb5ov8tfrq