Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity

Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here we report the abnormal high expression of circGlis3 in islets of male mice with obesity and serum of people with obesity. Increasing circGlis3 is regulated by Quaking (QKI)-mediated splicing circularization. circG...

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Detalles Bibliográficos
Autores principales: Liu, Yue, Yang, Yue, Xu, Chenying, Liu, Jianxing, Chen, Jiale, Li, Guoqing, Huang, Bin, Pan, Yi, Zhang, Yanfeng, Wei, Qiong, Pandol, Stephen J., Zhang, Fangfang, Li, Ling, Jin, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867769/
https://www.ncbi.nlm.nih.gov/pubmed/36681689
http://dx.doi.org/10.1038/s41467-023-35998-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867769/
https://www.ncbi.nlm.nih.gov/pubmed/36681689
http://dx.doi.org/10.1038/s41467-023-35998-z

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