Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

The Notch ligands Jag1 and Dll1 guide differentiation of multipotent pancreatic progenitor cells (MPCs) into unipotent pro-acinar cells (PACs) and bipotent duct/endocrine progenitors (BPs). Ligand-mediated trans-activation of Notch receptors induces oscillating expression of the transcription factor...

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Detalles Bibliográficos
Autores principales: Xu, Xiaochan, Seymour, Philip Allan, Sneppen, Kim, Trusina, Ala, Egeskov-Madsen, Anuska la Rosa, Jørgensen, Mette Christine, Jensen, Mogens Høgh, Serup, Palle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867774/
https://www.ncbi.nlm.nih.gov/pubmed/36681690
http://dx.doi.org/10.1038/s41467-023-35963-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867774/
https://www.ncbi.nlm.nih.gov/pubmed/36681690
http://dx.doi.org/10.1038/s41467-023-35963-w

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