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Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

The Notch ligands Jag1 and Dll1 guide differentiation of multipotent pancreatic progenitor cells (MPCs) into unipotent pro-acinar cells (PACs) and bipotent duct/endocrine progenitors (BPs). Ligand-mediated trans-activation of Notch receptors induces oscillating expression of the transcription factor...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaochan, Seymour, Philip Allan, Sneppen, Kim, Trusina, Ala, Egeskov-Madsen, Anuska la Rosa, Jørgensen, Mette Christine, Jensen, Mogens Høgh, Serup, Palle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867774/ https://www.ncbi.nlm.nih.gov/pubmed/36681690 http://dx.doi.org/10.1038/s41467-023-35963-w

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