Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo

Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory activity of lead compounds to levels previously unseen. The azetidine-based compounds, including H172 (9f) and H182, irr...

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Detalles Bibliográficos
Autores principales: Yue, Peibin, Zhu, Yinsong, Brotherton-Pleiss, Christine, Fu, Wenzhen, Verma, Nagendra, Chen, Jasmine, Nakamura, Kayo, Chen, Weiliang, Chen, Yue, Alonso-Valenteen, Felix, Mikhael, Simoun, Medina-Kauwe, Lali, Kershaw, Kathleen M., Celeridad, Maria, Pan, Songqin, Limpert, Allison S., Sheffler, Douglas J., Cosford, Nicholas D. P., Shiao, Stephen L., Tius, Marcus A., Lopez-Tapia, Francisco, Turkson, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867837/
https://www.ncbi.nlm.nih.gov/pubmed/35276290
http://dx.doi.org/10.1016/j.canlet.2022.215613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867837/
https://www.ncbi.nlm.nih.gov/pubmed/35276290
http://dx.doi.org/10.1016/j.canlet.2022.215613

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