PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8(+) T cells in breast cancer

Myeloid-derived suppressor cells (MDSCs) are an immature innate cell population that expands in pathological conditions such as cancer and suppresses T cells via production of immunosuppressive factors. Conversely, efficient cytotoxic T cell priming is dependent on the ability of antigen-presenting...

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Detalles Bibliográficos
Autores principales: Chaib, Mehdi, Sipe, Laura M., Yarbro, Johnathan R., Bohm, Margaret S., Counts, Brittany R., Tanveer, Ubaid, Pingili, Ajeeth K., Daria, Deidre, Marion, Tony N., Carson, James A., Thomas, Paul G., Makowski, Liza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867936/
https://www.ncbi.nlm.nih.gov/pubmed/35074498
http://dx.doi.org/10.1016/j.canlet.2022.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9867936/
https://www.ncbi.nlm.nih.gov/pubmed/35074498
http://dx.doi.org/10.1016/j.canlet.2022.01.017

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