Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model

INTRODUCTION: Soft tissue sarcomas (STS) are highly metastatic, connective-tissue lineage solid cancers. Immunologically, sarcomas are frequently characterized by a paucity of tumor infiltrating lymphocytes and an immune suppressive microenvironment. Activation of the STING pathway can induce potent...

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Detalles Bibliográficos
Autores principales: Marritt, Kayla L., Hildebrand, Karys M., Hildebrand, Kurt N., Singla, Arvind K., Zemp, Franz J., Mahoney, Douglas J., Jirik, Frank R., Monument, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868147/
https://www.ncbi.nlm.nih.gov/pubmed/36700206
http://dx.doi.org/10.3389/fimmu.2022.1087991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868147/
https://www.ncbi.nlm.nih.gov/pubmed/36700206
http://dx.doi.org/10.3389/fimmu.2022.1087991

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