Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department

BACKGROUND: Vaso-occlusive pain crisis (VOC) is the most frequent cause for Emergency Department (ED) visits and hospital admissions for patients with sickle cell disease (SCD). Nitric oxide plays a critical role in the pathogenesis of vaso-occlusion. The amino acid, citrulline, is the main endothel...

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Detalles Bibliográficos
Autores principales: Majumdar, S., McKinley, K.W., Chamberlain, J., Thomas, B., Margulies, S., Nickel, R.S., Darbari, D.S., Campbell, A., Berul, C., Summar, M., Kalsi, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868327/
https://www.ncbi.nlm.nih.gov/pubmed/36698745
http://dx.doi.org/10.1016/j.conctc.2023.101077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868327/
https://www.ncbi.nlm.nih.gov/pubmed/36698745
http://dx.doi.org/10.1016/j.conctc.2023.101077

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