Cargando…

Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department

BACKGROUND: Vaso-occlusive pain crisis (VOC) is the most frequent cause for Emergency Department (ED) visits and hospital admissions for patients with sickle cell disease (SCD). Nitric oxide plays a critical role in the pathogenesis of vaso-occlusion. The amino acid, citrulline, is the main endothel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Majumdar, S., McKinley, K.W., Chamberlain, J., Thomas, B., Margulies, S., Nickel, R.S., Darbari, D.S., Campbell, A., Berul, C., Summar, M., Kalsi, G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868327/ https://www.ncbi.nlm.nih.gov/pubmed/36698745 http://dx.doi.org/10.1016/j.conctc.2023.101077

Ejemplares similares

5613043 THE EVOLUTION OF THE COVID-19 PANDEMIC IN PEDIATRIC PATIENTS WITH SICKLE CELL DISEASE: FROM ALPHA TO OMICRON
por: Martin, O.Y., et al.
Publicado: (2023)

Pediatric Sickle Cell Disease and the COVID-19 Pandemic: A Year in Review at Children's National Hospital
por: Martin, Olufunke Y., et al.
Publicado: (2021)

5616493 MACHINE LEARNING TO IDENTIFY CHILDREN WITH SICKLE CELL DISEASE AT VERY LOW HIGH RISK OF ABNORMAL OR CONDITIONAL TRANSCRANIAL DOPPLER SCREENING.
por: McKinley, K.W.M., et al.
Publicado: (2023)

Clinical outcomes of children and adolescents with sickle cell disease and COVID-19 infection: A year in review at a metropolitan tertiary pediatric hospital
por: Martin, Olufunke Y., et al.
Publicado: (2023)

Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis
por: McKinley-Barnard, Sarah, et al.
Publicado: (2015)

5613480 REAL WORLD APPLICATIONS OF CLINICAL WHOLE BLOOD ADHESION (VCAM AND P-SELECTIN) BIOMARKERS IN A PEDIATRIC SCD POPULATION
por: Martin, O.Y., et al.
Publicado: (2023)

5613459 PAIN IN YOUTH WITH SICKLE CELL DISEASE AND ASSOCIATION WITH SLEEP
por: Hyppolite, R.H., et al.
Publicado: (2023)

5616412 SOCIAL DETERMINANTS OF HEALTH AND THEIR IMPACT ON FAMILIES OF CHILDREN WITH SICKLE CELL DISEASE DURING COVID-19 PANDEMIC
por: Margulies, S.L.M., et al.
Publicado: (2023)

Reduction in vaso-occlusive events following stem cell transplantation in patients with sickle cell disease
por: Leonard, Alexis, et al.
Publicado: (2022)

Intravenous Fluid Administration and the Risk of Adverse Outcomes in Sickle Cell Disease Patients Hospitalized for Vaso-Occlusive Crisis
por: Ojo, Ademola S., et al.
Publicado: (2022)

P-065: IMPACT OF SOCIOECONOMIC FACTORS ON COGNITIVE FUNCTION IN CHILDREN AND ADOLESCENTS WITH SICKLE CELL DISEASE
por: A., DARBARI, et al.
Publicado: (2022)

Fluid overload due to intravenous fluid therapy for vaso‐occlusive crisis in sickle cell disease: incidence and risk factors
por: Gaartman, Aafke E., et al.
Publicado: (2021)

Tackling sickle cell crisis in Nigeria: the need for newer therapeutic solutions in sickle cell crisis management – short communication
por: Mary Nnagha, Ekene, et al.
Publicado: (2023)

Impact of Universal Suicide Risk Screening in a Pediatric Emergency Department: A Discrete Event Simulation Approach
por: McKinley, Kenneth W., et al.
Publicado: (2022)

The Day I Relearned the Sickle Cell Crisis
por: Hibbs, Stephen, et al.
Publicado: (2022)

Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis
por: Ware, Lorraine B, et al.
Publicado: (2013)

Intravenous citrulline generation test to assess intestinal function in intensive care unit patients
por: Peters, Job HC, et al.
Publicado: (2017)

Eight weeks of resistance training in conjunction with glutathione and L-Citrulline supplementation increases lean mass and has no adverse effects on blood clinical safety markers in resistance-trained males
por: Hwang, Paul, et al.
Publicado: (2018)

Folic acid, either solely or combined with L‐citrulline, improves NO signaling and ameliorates chronic hypoxia‐induced pulmonary hypertension in newborn pigs
por: Douglass, Matthew, et al.
Publicado: (2021)

Fatal sickling-associated microvascular occlusive crisis in a young with sickle cell trait
por: Mutreja, Deepti, et al.
Publicado: (2021)

Reducing Pediatric ED Length of Stay by Reducing Diagnostic Testing: A Discrete Event Simulation Model
por: McKinley, Kenneth W., et al.
Publicado: (2021)

Resolution of Sickle Cell Crisis Following Administration of Amiodarone
por: Silaghi, Paul, et al.
Publicado: (2023)

Sodium-Coupled Neutral Amino Acid Transporter 1 (SNAT1) Modulates L-Citrulline Transport and Nitric Oxide (NO) Signaling in Piglet Pulmonary Arterial Endothelial Cells
por: Dikalova, Anna, et al.
Publicado: (2014)

Provider Perspective on Integrative Medicine for Pediatric Sickle Cell Disease–related Pain
por: Neri, Caitlin M., et al.
Publicado: (2016)

COVID19 vaccination in adults with sickle cell disease is not associated with increases in rates of pain crisis
por: Friedman, Elana, et al.
Publicado: (2022)

Improving the Emergency Department Management of Sickle Cell Vaso-Occlusive Pain Crisis: The Role and Options of Sublingual and Intranasally Administered Analgesia
por: Ojo, Ademola S., et al.
Publicado: (2023)

5610178 SURVIVAL AND COMPLICATIONS IN PATIENTS WITH HEMOGLOBINOPATHIES: THE EXPERIENCE OF A SINGLE DEPARTMENT OF THALASSEMIA AND SICKLE DISEASE
por: Xydaki, X.A., et al.
Publicado: (2023)

The post-mortem diagnosis of vasocclusive crisis in sickle cell disease
por: Bhatia, Varsha, et al.
Publicado: (2014)

A Sickle Cell Crisis in a Blood Culture Bottle
por: Kamada, Keisuke, et al.
Publicado: (2019)

Pheochromocytoma Crisis in the Emergency Department
por: Bartikoski, Stephanie R, et al.
Publicado: (2021)

Hyperhemolytic Crisis Following Transfusion in Sickle Cell Disease With Acute Hepatic Crisis: A Case Report
por: Trivedi, Krunal, et al.
Publicado: (2022)

Sickle cell bone disease and response to intravenous bisphosphonates in children
por: Grimbly, C., et al.
Publicado: (2022)

Magnetic Resonance Imaging Utilization in an Emergency Department Observation Unit
por: Sánchez, Yadiel, et al.
Publicado: (2017)

A flexible simulation platform to quantify and manage emergency department crowding
por: Hurwitz, Joshua E, et al.
Publicado: (2014)

Brodie's Abscess in a Patient Presenting with Sickle Cell Vasoocclusive Crisis
por: Ogbonna, Onyekachi Henry, et al.
Publicado: (2015)

Sickle cell vaso-occlusive crisis: it’s a gut feeling
por: Lim, Seah H., et al.
Publicado: (2016)

Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia
por: Alkindi, S., et al.
Publicado: (2021)

Spontaneous Epidural Hematoma in Sickle Cell Crisis: A Case Report
por: Joy, Jiss, et al.
Publicado: (2022)

Revisiting Arginine Therapy for Sickle Cell Acute Vasoocclusive Painful Crisis
por: Hopper, Rachel K., et al.
Publicado: (2022)

The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment
por: Elkayam, Ori, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mgfo5l28ekajj7vfp6ec433s8i