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Computational protein design repurposed to explore enzyme vitality and help predict antibiotic resistance
In response to antibiotics that inhibit a bacterial enzyme, resistance mutations inevitably arise. Predicting them ahead of time would aid target selection and drug design. The simplest resistance mechanism would be to reduce antibiotic binding without sacrificing too much substrate binding. The pro...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868620/ https://www.ncbi.nlm.nih.gov/pubmed/36699702 http://dx.doi.org/10.3389/fmolb.2022.905588 |