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Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies

T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new drug modality. However, we lack a general understanding of how TCRms engage pMHC targets, which is crucial for predicting their speci...

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Detalles Bibliográficos
Autores principales: Raybould, Matthew I. J., Nissley, Daniel A., Kumar, Sandeep, Deane, Charlotte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868621/
https://www.ncbi.nlm.nih.gov/pubmed/36700202
http://dx.doi.org/10.3389/fimmu.2022.1080596