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Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways

Osteoarthritis (OA) is a trauma-/age-related degenerative disease characterized by chronic inflammation as one of its pathogenic mechanisms. Mulberroside A (MA), a natural bioactive withanolide, demonstrates anti-inflammatory properties in various diseases; however, little is known about the effect...

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Detalles Bibliográficos
Autores principales: Lu, Rui, Wei, Zhenni, Wang, Zhenggang, Xu, Shimeng, Sun, Kai, Cheng, Peng, Huang, Xiaojian, You, Hongbo, Guo, Fengjing, Liang, Shuang, Chen, An-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9868682/
https://www.ncbi.nlm.nih.gov/pubmed/36698724
http://dx.doi.org/10.1016/j.isci.2023.105936