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Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022

INTRODUCTION: Bacterial meningitis (BM) is an infectious disease with high morbidity and mortality rates in children. Although vaccination has improved prevention of BM, this severe disease continues to cause considerable harm to children across the globe. Several risk factors have been identified f...

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Autores principales: Chen, Danchun, Tang, Benyu, Li, Ying, Zheng, Kelu, Li, Xiaojing, Chen, Wenxiong, Gao, Fei, Gao, Yuanyuan, Shi, Kaili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869027/
https://www.ncbi.nlm.nih.gov/pubmed/36699723
http://dx.doi.org/10.3389/fcimb.2022.1092468
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author Chen, Danchun
Tang, Benyu
Li, Ying
Zheng, Kelu
Li, Xiaojing
Chen, Wenxiong
Gao, Fei
Gao, Yuanyuan
Shi, Kaili
author_facet Chen, Danchun
Tang, Benyu
Li, Ying
Zheng, Kelu
Li, Xiaojing
Chen, Wenxiong
Gao, Fei
Gao, Yuanyuan
Shi, Kaili
author_sort Chen, Danchun
collection PubMed
description INTRODUCTION: Bacterial meningitis (BM) is an infectious disease with high morbidity and mortality rates in children. Although vaccination has improved prevention of BM, this severe disease continues to cause considerable harm to children across the globe. Several risk factors have been identified for BM, including immune status, age, and sex. However, additional patient and disease information is required in order to better understand the local characteristics, epidemiology and risk factors of BM. METHODS: Here, we collected information from 252 children with BM in the Guangzhou Women and Children Medical Centre medical record database infected with Streptococcus agalactiae, Streptococcus pneumoniae, or Escherichia coli between May 2015 and May 2022. RESULTS: The three pathogen infected BM cased showed distinct trends during the period, and distribution of three BM pathogens across age groups varied significantly. We reviewed the antimicrobial resistance patterns for each of the pathogens which may direct drug use in BM. Finally, we found blood WBC was a protective factor, while glucose levels in the CFS was risk factor, for the length of hospitalization. DISCUSSION: Collectively, this study provides multi-parameter characteristics of BM, and potentially guide the drug use.
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spelling pubmed-98690272023-01-24 Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022 Chen, Danchun Tang, Benyu Li, Ying Zheng, Kelu Li, Xiaojing Chen, Wenxiong Gao, Fei Gao, Yuanyuan Shi, Kaili Front Cell Infect Microbiol Cellular and Infection Microbiology INTRODUCTION: Bacterial meningitis (BM) is an infectious disease with high morbidity and mortality rates in children. Although vaccination has improved prevention of BM, this severe disease continues to cause considerable harm to children across the globe. Several risk factors have been identified for BM, including immune status, age, and sex. However, additional patient and disease information is required in order to better understand the local characteristics, epidemiology and risk factors of BM. METHODS: Here, we collected information from 252 children with BM in the Guangzhou Women and Children Medical Centre medical record database infected with Streptococcus agalactiae, Streptococcus pneumoniae, or Escherichia coli between May 2015 and May 2022. RESULTS: The three pathogen infected BM cased showed distinct trends during the period, and distribution of three BM pathogens across age groups varied significantly. We reviewed the antimicrobial resistance patterns for each of the pathogens which may direct drug use in BM. Finally, we found blood WBC was a protective factor, while glucose levels in the CFS was risk factor, for the length of hospitalization. DISCUSSION: Collectively, this study provides multi-parameter characteristics of BM, and potentially guide the drug use. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9869027/ /pubmed/36699723 http://dx.doi.org/10.3389/fcimb.2022.1092468 Text en Copyright © 2023 Chen, Tang, Li, Zheng, Li, Chen, Gao, Gao and Shi https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Chen, Danchun
Tang, Benyu
Li, Ying
Zheng, Kelu
Li, Xiaojing
Chen, Wenxiong
Gao, Fei
Gao, Yuanyuan
Shi, Kaili
Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title_full Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title_fullStr Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title_full_unstemmed Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title_short Characteristics and risk factors of bacterial meningitis caused by Streptococcus agalactiae, Streptococcus pneumoniae or Escherichia coli in Guangzhou China from 2015 to 2022
title_sort characteristics and risk factors of bacterial meningitis caused by streptococcus agalactiae, streptococcus pneumoniae or escherichia coli in guangzhou china from 2015 to 2022
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869027/
https://www.ncbi.nlm.nih.gov/pubmed/36699723
http://dx.doi.org/10.3389/fcimb.2022.1092468
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