Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (Ig) repertoires. The ubiquitin E3 ligase HUWE1 controls proliferation, DNA damage responses, and DNA repair, including the base excision repair (BER) pathway....

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Detalles Bibliográficos
Autores principales: Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C. M., Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J. I., Pardieck, Iris N., Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E. J., Jacobs, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869049/
https://www.ncbi.nlm.nih.gov/pubmed/36700204
http://dx.doi.org/10.3389/fimmu.2022.986863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869049/
https://www.ncbi.nlm.nih.gov/pubmed/36700204
http://dx.doi.org/10.3389/fimmu.2022.986863

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