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Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

Activation of cellular hypoxia pathways, orchestrated by HIF (hypoxia-inducible factor) transcription factors, is a common feature of multiple tumor types, resulting from microenvironment factors and oncogenic mutation. Although they help drive many of the “hallmarks” of cancer and are associated wi...

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Detalles Bibliográficos
Autores principales: Lombardi, Olivia, Li, Ran, Halim, Silvia, Choudhry, Hani, Ratcliffe, Peter J., Mole, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869179/
https://www.ncbi.nlm.nih.gov/pubmed/36384128
http://dx.doi.org/10.1016/j.celrep.2022.111652