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Exploring PROTAC Cooperativity with Coarse-Grained Alchemical Methods
[Image: see text] Proteolysis targeting chimera (PROTAC) is a novel drug modality that facilitates the degradation of a target protein by inducing proximity with an E3 ligase. In this work, we present a new computational framework to model the cooperativity between PROTAC–E3 binding and PROTAC–targe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869335/ https://www.ncbi.nlm.nih.gov/pubmed/36607139 http://dx.doi.org/10.1021/acs.jpcb.2c05795 |