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Rb deficiency, neuronal survival and neurodegeneration: In search of the perfect mouse model

Three decades following the introduction of the first Rb knockout (KO) mouse model, the role of this critical protein in regulating brain development during embryogenesis and beyond remains a major scientific interest. Rb is a tumor suppressor gene known as the master regulator of the G1/S checkpoin...

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Detalles Bibliográficos
Autores principales: Omais, Saad, El Atie, Yara E., Ghanem, Noël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869410/
https://www.ncbi.nlm.nih.gov/pubmed/36699152
http://dx.doi.org/10.1016/j.crneur.2023.100074