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The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice

BACKGROUND: Previous studies have shown that depression is often accompanied by an increase in mtDNA copy number and a decrease in ATP levels; however, the exact regulatory mechanisms remain unclear. METHODS: In the present study, Western blot, cell knockdown, immunofluorescence, immunoprecipitation...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Shi, Haixia, Yang, Bo, Miao, Zhigang, Sun, Miao, Yang, Hao, Xu, Xingshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869592/
https://www.ncbi.nlm.nih.gov/pubmed/36691038
http://dx.doi.org/10.1186/s12964-022-01034-8