Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity

Recombinant adenovirus serotype 5 (Ad5) vector has been widely applied in vaccine development targeting infectious diseases, such as Ebola virus disease and coronavirus disease 2019 (COVID-19). However, the high prevalence of preexisting anti-vector immunity compromises the immunogenicity of Ad5-bas...

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Detalles Bibliográficos
Autores principales: Yang, Yilong, Wu, Shipo, Wang, Yudong, Shao, Fangze, Lv, Peng, Li, Ruihua, Zhao, Xiaofan, Zhang, Jun, Zhang, Xiaopeng, Li, Jianmin, Hou, Lihua, Xu, Junjie, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company. 2023
Materias:
Research Medical Engineering–Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869631/
https://www.ncbi.nlm.nih.gov/pubmed/36714358
http://dx.doi.org/10.1016/j.eng.2022.12.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869631/
https://www.ncbi.nlm.nih.gov/pubmed/36714358
http://dx.doi.org/10.1016/j.eng.2022.12.007

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