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Ablation of CXCR4 expression in cardiomyocytes exacerbates isoproterenol-induced cell death and heart failure

CXCR4 is a seven-transmembrane-spanning Gi-coupled receptor for the SDF-1 chemokine and plays a critical role in cardiovascular development and post-injury repair. However, the specific role of CXCR4 in cardiomyocytes is incompletely understood. It was hypothesized that CXCR4 activation in cardiomyo...

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Detalles Bibliográficos
Autores principales: Cheng, Min, Chen, Can, Yu, Kunwu, Lv, Xiao, Zeng, Qiutang, Dong, Nianguo, Zhu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869727/
https://www.ncbi.nlm.nih.gov/pubmed/36579657
http://dx.doi.org/10.3892/ijmm.2022.5216