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Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum

BACKGROUND AND OBJECTIVES: We previously found that the APOE genotype affects the rate of cognitive decline in mild-to-moderate Alzheimer disease (AD) dementia independently of its effects on AD neuropathologic changes (ADNC) and copathologies. In this study, we tested the hypothesis that the APOE a...

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Detalles Bibliográficos
Autores principales: Qian, Jing, Zhang, Yiding, Betensky, Rebecca A., Hyman, Bradley T., Serrano-Pozo, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869750/
https://www.ncbi.nlm.nih.gov/pubmed/36698453
http://dx.doi.org/10.1212/NXG.0000000000200055