BRCA1 and TP53 codeficiency causes a PARP inhibitor–sensitive erythroproliferative neoplasm

Mutations in the BRCA1 tumor suppressor gene, such as 5382insC (BRCA1(insC)), give carriers an increased risk for breast, ovarian, prostate, and pancreatic cancers. We have previously reported that, in mice, Brca1 deficiency in the hematopoietic system leads to pancytopenia and, as a result, early l...

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Detalles Bibliográficos
Autores principales: Lopez-Perez, Gerardo, Wijayatunge, Ranjula, McCrum, Kelly B., Holmstrom, Sam R., Mgbemena, Victoria E., Ross, Theodora S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869974/
https://www.ncbi.nlm.nih.gov/pubmed/36346676
http://dx.doi.org/10.1172/jci.insight.158257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869974/
https://www.ncbi.nlm.nih.gov/pubmed/36346676
http://dx.doi.org/10.1172/jci.insight.158257

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