Cargando…

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

A series of 1H-benzo[f]chromene moieties (4a–z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: MCF-7, HC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al‑Harbi, Lali M., Al-Harbi, Eman A., Okasha, Rawda M., El-Eisawy, R. A., El-Nassag, Mohammed A. A., Mohamed, Hany M., Fouda, Ahmed M., Elhenawy, Ahmed A., Mora, Ahmed, El-Agrody, Ahmed M., El-Mawgoud, Heba K. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869995/ https://www.ncbi.nlm.nih.gov/pubmed/36662632 http://dx.doi.org/10.1080/14756366.2022.2155814

Ejemplares similares

Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects
por: Albalawi, Fawzia F., et al.
Publicado: (2022)

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect
por: Ahmed, Hany E. A., et al.
Publicado: (2018)

Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives
por: Okasha, Rawda M., et al.
Publicado: (2016)

Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis
por: Alblewi, Fawzia F., et al.
Publicado: (2019)

Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions
por: Okasha, Rawda M., et al.
Publicado: (2017)

Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7(ADR) breast cancer cells
por: Abdel-Sattar, Ola E., et al.
Publicado: (2023)

Synthesis and Biological Screening of 4-Benzyl-2H-phthalazine Derivatives
por: El-Wahab, Ashraf H.F. Abd, et al.
Publicado: (2011)

Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms
por: Elgaafary, Menna, et al.
Publicado: (2021)

In Vitro Cytotoxic Study of Euphorbia grantii Oliv. Aerial Parts against MCF-7 and MCF-7(ADR) Breast Cancer Cell Lines: A Bioactivity-Guided Isolation
por: Radi, Mai Hussin, et al.
Publicado: (2023)

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors
por: Halawa, Ahmed H., et al.
Publicado: (2019)

Cinchona officinalis Phytochemicals-Loaded Iron Oxide Nanoparticles Induce Cytotoxicity and Stimulate Apoptosis in MCF-7 Human Breast Cancer Cells
por: Al-Harbi, Laila Naif, et al.
Publicado: (2022)

Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial and anticancer agents
por: Afifi, Tarek H., et al.
Publicado: (2017)

Ethyl 2-amino-4-(4-bromophenyl)-6-methoxy-4H-benzo[h]chromene-3-carboxylate
por: El-Agrody, Ahmed M., et al.
Publicado: (2013)

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways
por: El-Agamy, Dina S, et al.
Publicado: (2018)

Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents
por: Elhenawy, Ahmed A, et al.
Publicado: (2019)

A Novel Electrochemical Differentiation between Exosomal-RNA of Breast Cancer MCF7 and MCF7/ADR-Resistant Cells
por: Abdelaziz, Mohammed H., et al.
Publicado: (2023)

Synthesis, Reactions and Antimicrobial Activities of 8-Ethoxycoumarin Derivatives
por: Mohamed, Hany M., et al.
Publicado: (2012)

Efficacy of Live Attenuated Vaccine and Commercially Available Lectin against Avian Pathogenic E. coli Infection in Broiler Chickens
por: Abd El-Mawgoud, Ahmed I., et al.
Publicado: (2020)

Wood ash biocatalyst as a novel green catalyst and its application for the synthesis of benzochromene derivatives
por: Rostamian, Rezvaneh, et al.
Publicado: (2022)

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities
por: Mohamed, Hany M, et al.
Publicado: (2011)

Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer
por: Doghish, Ahmed S., et al.
Publicado: (2021)

Low host specificity of Hippobosca equina infestation in different domestic animals and pigeon
por: Soliman, Soliman M., et al.
Publicado: (2022)

Ecofriendly Long Life Nanocomposite Sensors for Determination of Carbachol in Presence of Choline: Application in Ophthalmic Solutions and Biological Fluids
por: Al-Harbi, Eman A., et al.
Publicado: (2019)

Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment
por: Ahmed, Saleh A., et al.
Publicado: (2017)

The Effect of Different Routes of Injection of Bone Marrow Mesenchymal Stem Cells on Parotid Glands of Rats Receiving Cisplatin: A Comparative Study
por: Hany, Eman, et al.
Publicado: (2017)

Development of a Novel Series of Anticancer and Antidiabetic: Spirothiazolidines Analogs
por: Flefel, Eman M., et al.
Publicado: (2019)

N(α)-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation
por: Naglah, Ahmed M, et al.
Publicado: (2021)

Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale
por: Okasha, Rawda M., et al.
Publicado: (2019)

Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms
por: Malebari, Azizah M., et al.
Publicado: (2023)

Can Symbiotic Bacteria (Xenorhabdus and Photorhabdus) Be More Efficient than Their Entomopathogenic Nematodes against Pieris rapae and Pentodon algerinus Larvae?
por: Elbrense, Hanaa, et al.
Publicado: (2021)

Cationic Cyclopentadienyliron Complex as a Novel and Successful Nucleating Agent on the Crystallization Behavior of the Biodegradable PHB Polymer
por: El-Taweel, Safaa H., et al.
Publicado: (2018)

Synthesis, Reactions and Biological Evaluation of Some New Naphtho[2,1-b]furan Derivatives Bearing a Pyrazole Nucleus
por: El-Wahab, Ashraf H. F. Abd, et al.
Publicado: (2011)

New morphological and molecular data on the little-known pontellid Calanopia media Gurney, 1927 (Crustacea, Copepoda, Calanoida) from the Red Sea, with notes on its diel vertical distribution
por: El-Sherbiny, Mohsen M., et al.
Publicado: (2020)

Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin
por: Abdalla, Ashraf N., et al.
Publicado: (2021)

Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma
por: Ahmed, Osama A. A., et al.
Publicado: (2021)

Acetylcholine Esterase Inhibitory Effect, Antimicrobial, Antioxidant, Metabolomic Profiling, and an In Silico Study of Non-Polar Extract of The Halotolerant Marine Fungus Penicillium chrysogenum MZ945518
por: El-Sayed, Heba, et al.
Publicado: (2023)

Do Morphological Changes in the Anterior Mandibular Region Interfere with Standard Implant Placement? A Cone Beam Computed Tomographic Cross-Sectional Study
por: Fouda, Shaimaa M., et al.
Publicado: (2020)

3-Amino-1-(4-fluorophenyl)-8-methoxy-1H-benzo[f]chromene-2-carbonitrile
por: El-Agrody, Ahmed M., et al.
Publicado: (2013)

3-Amino-1-(4-fluorophenyl)-7-methoxy-1H-benzo[f]chromene-2-carbonitrile
por: Amr, Abd El-Galil E., et al.
Publicado: (2013)

2-(4-Fluorobenzylidene)propanedinitrile: monoclinic polymorph
por: El-Agrody, Ahmed M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7h4oak8lktboj3n6k4hgnq111i