ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis

FOXD1(+) cell–derived stromal cells give rise to pericytes and fibroblasts that support the kidney vasculature and interstitium but are also major precursors of myofibroblasts. ZEB2 is a SMAD-interacting transcription factor that is expressed in developing kidney stromal progenitors. Here we show th...

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Detalles Bibliográficos
Autores principales: Kumar, Sudhir, Fan, Xueping, Rasouly, Hila Milo, Sharma, Richa, Salant, David J., Lu, Weining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870089/
https://www.ncbi.nlm.nih.gov/pubmed/36445780
http://dx.doi.org/10.1172/jci.insight.158418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870089/
https://www.ncbi.nlm.nih.gov/pubmed/36445780
http://dx.doi.org/10.1172/jci.insight.158418

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