Cargando…

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis

FOXD1(+) cell–derived stromal cells give rise to pericytes and fibroblasts that support the kidney vasculature and interstitium but are also major precursors of myofibroblasts. ZEB2 is a SMAD-interacting transcription factor that is expressed in developing kidney stromal progenitors. Here we show th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Sudhir, Fan, Xueping, Rasouly, Hila Milo, Sharma, Richa, Salant, David J., Lu, Weining
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870089/ https://www.ncbi.nlm.nih.gov/pubmed/36445780 http://dx.doi.org/10.1172/jci.insight.158418

Ejemplares similares

Decoding myofibroblast origins in human kidney fibrosis
por: Kuppe, Christoph, et al.
Publicado: (2021)

Pitfalls and Challenges of Consenting to Genetic Research Studies
por: Milo Rasouly, Hila, et al.
Publicado: (2018)

Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface
por: Valatas, Vassilis, et al.
Publicado: (2017)

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis
por: Zhao, Qianwen, et al.
Publicado: (2023)

Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
por: Das, Amrita, et al.
Publicado: (2013)

miR‐200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2
por: Liao, Yi‐Wen, et al.
Publicado: (2018)

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis
por: Yao, Liudi, et al.
Publicado: (2018)

Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis
por: Bijkerk, Roel, et al.
Publicado: (2019)

Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
por: Xiong, Yunzhao, et al.
Publicado: (2021)

Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts
por: Chen, Guochun, et al.
Publicado: (2012)

Rare presentation of inflammatory myofibroblastic tumor in the kidney
por: Abduljawad, Hiba, et al.
Publicado: (2020)

Inhibition of Fatty Acid–Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition
por: Feng, Yanhuan, et al.
Publicado: (2020)

Biofabricated 3D in vitro model of fibrosis‐induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver
por: Brovold, Matthew, et al.
Publicado: (2021)

Vitamin D deficiency contributes to the diabetic kidney disease progression via increase ZEB1/ZEB2 expressions
por: Souza, Cláudia Silva, et al.
Publicado: (2023)

Loss of Jagged1 in renin progenitors leads to focal kidney fibrosis
por: Belyea, Brian C, et al.
Publicado: (2015)

Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1
por: Chang, Yu-Chao, et al.
Publicado: (2014)

Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis: A case report and literature review
por: Sun, Zhuolun, et al.
Publicado: (2017)

Origin of myofibroblasts in liver fibrosis
por: Brenner, David A, et al.
Publicado: (2012)

Inflammatory Myofibroblastic Tumor of the Kidney Misdiagnosed as Renal Cell Carcinoma
por: Ryu, Kwang Ho, et al.
Publicado: (2010)

Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors
por: Ohmori, Tomoko, et al.
Publicado: (2015)

Neutral endopeptidase inhibitors SOL-1 and candoxatril counteract kidney fibrosis by reducing myofibroblast formation in mouse UUO model
por: Aleksinskaya, Marina, et al.
Publicado: (2013)

Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis
por: Kobayashi, Akio, et al.
Publicado: (2014)

Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
por: Liu, Peng, et al.
Publicado: (2020)

Expression of calponin in periglomerular myofibroblasts of rat kidney with experimental chronic injuries
por: Lee, So-Young, et al.
Publicado: (2010)

Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys
por: Srivastava, Swayam Prakash, et al.
Publicado: (2021)

SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis
por: Srivastava, Swayam Prakash, et al.
Publicado: (2018)

Abnormal Position of the Kidney
por: Harger, S. J. J.
Publicado: (1898)

Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts?
por: Ortiz-Zapater, Elena, et al.
Publicado: (2022)

LINC00084/miR-204/ZEB1 Axis Mediates Myofibroblastic Differentiation Activity in Fibrotic Buccal Mucosa Fibroblasts: Therapeutic Target for Oral Submucous Fibrosis
por: Lee, Yu-Hsien, et al.
Publicado: (2021)

Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression
por: Chang, Yu-Chao, et al.
Publicado: (2016)

Correction to: Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
por: Liu, Peng, et al.
Publicado: (2023)

Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue
por: Jager, Mike, et al.
Publicado: (2018)

Expression of E-cadherin repressors SNAIL, ZEB1 and ZEB2 by tumour and stromal cells influences tumour-budding phenotype and suggests heterogeneity of stromal cells in pancreatic cancer
por: Galván, J A, et al.
Publicado: (2015)

Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis
por: Lu, Sizhao, et al.
Publicado: (2020)

Redistribution of the chromatin remodeler Brg1 directs smooth muscle–derived adventitial progenitor–to–myofibroblast differentiation and vascular fibrosis
por: Jolly, Austin J., et al.
Publicado: (2023)

Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2018)

Zeb1 Regulates the Function of Lympho-Myeloid Primed Progenitors after Transplantation
por: Almotiri, Alhomidi, et al.
Publicado: (2023)

Swimming Exercise Prevents Fibrogenesis in Chronic Kidney Disease by Inhibiting the Myofibroblast Transdifferentiation
por: Peng, Chiung-Chi, et al.
Publicado: (2012)

The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury
por: Gomez, Ivan G, et al.
Publicado: (2014)

Child inflammatory myofibroblastic tumor of the kidney misdiagnosed as Wilms' tumor: case report
por: Bai, Yu-Feng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k2mkbtnp6h5sb0d49o3iqupvud