The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic nephropathy, is characterized by phenotypic variability that exceeds genic effects. Dysregulated metabolism and immune cell function are key disease modifiers. The tryptophan metabolites, kynurenines, produced through in...

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Detalles Bibliográficos
Autores principales: Nguyen, Dustin T., Kleczko, Emily K., Dwivedi, Nidhi, Monaghan, Marie-Louise T., Gitomer, Berenice Y., Chonchol, Michel B., Clambey, Eric T., Nemenoff, Raphael A., Klawitter, Jelena, Hopp, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870090/
https://www.ncbi.nlm.nih.gov/pubmed/36422996
http://dx.doi.org/10.1172/jci.insight.154773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870090/
https://www.ncbi.nlm.nih.gov/pubmed/36422996
http://dx.doi.org/10.1172/jci.insight.154773

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