Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI). We found that endoplasmic reticulum (ER) stress genes were coupregulated with MitoCarta genes in chr...

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Detalles Bibliográficos
Autores principales: Saaoud, Fatma, Liu, Lu, Xu, Keman, Cueto, Ramon, Shao, Ying, Lu, Yifan, Sun, Yu, Snyder, Nathaniel W., Wu, Sheng, Yang, Ling, Zhou, Yan, Williams, David L., Li, Chuanfu, Martinez, Laisel, Vazquez-Padron, Roberto I., Zhao, Huaqing, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870092/
https://www.ncbi.nlm.nih.gov/pubmed/36394956
http://dx.doi.org/10.1172/jci.insight.158183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870092/
https://www.ncbi.nlm.nih.gov/pubmed/36394956
http://dx.doi.org/10.1172/jci.insight.158183

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